One of the RARE Drugs that Actually Helps Your Body to Heal Itself Posted By Dr. Mercola
September 19 2011
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Story at-a-glance
Low-dose naltrexone (LDN) has shown promise in activating your immune system, offering impressive benefit in the treatment of cancer and autoimmune disorders
LDN is inexpensive and is not backed by any major drug company because potential profits are minimal. As result, it has not been widely publicized and many physicians are not familiar with it.
LDN does not treat symptoms as most drugs do; it helps regulate bodily mechanisms that can result in a disease state
By Dr. Mercola
It is not often that I advocate the use of prescription drugs, but low-dose naltrexone (LDN) is one of those rare exceptions that may hold the promise of helping millions of people with cancer and autoimmune disease.
As a pharmacologically active opioid antagonist, LDN works by blocking opioid receptors, which in turn helps activate your body's immune system.
How LDN Harnesses Your Own Body's Chemistry to Fight Disease
The latest research in Experimental Biology and Medicine just confirmed that LDN does in fact target the opioid growth factor (OGF)/opioid growth factor receptor (OGFr) pathway to inhibit cell proliferation. Previous research by professor Ian S. Zagon of The Pennsylvania State University, who also conducted the Experimental Biology and Medicine study, found that OGF regulates the growth of cancer cells, and all cancer cells use the OGF-OGFr pathway in growth regulation.
It is through this mechanism that LDN is thought to exert its profound inhibitory effect on cancer growth.
Further, LDN also works with your body's immune system through its interactions with your body's endorphins. Though most commonly referenced in relation to you mood, endorphins also play a role in pain relief, immune system regulation, growth of cells and angiogenesis (the growth of blood vessels that feed a tumor).
Typically, LDN is taken at bedtime, which blocks your opioid receptors, as well as the reception of endorphins, for a few hours in the middle of the night. This is believed to up-regulate vital elements of your immune system by increasing your body's production of metenkephalin and endorphins (your natural opioids), hence improving your immune function.
In addition to cancer, LDN has shown promise for the treatment of the following diseases:
Hepatitis C Diabetic neuropathies
Lupus Dermatomyositis (an inflammatory muscle disease)
Ulcerative colitis Multiple sclerosis
Autism Crohn's disease
Chronic fatigue syndrome Alzheimer's disease
HIV/AIDS Hasimoto's thyroiditis
Irritable bowel syndrome (IBS) Parkinson's disease
How can one substance impact so many different diseases? As written on the non-profit Web site LowDoseNaltrexone.org, which is an excellent resource for more information:
"The disorders listed above all share a particular feature: in all of them, the immune system plays a central role. Low blood levels of endorphins are generally present, contributing to the disease-associated immune deficiencies."
Impressive Results in Cancer Treatment
In 1985, Dr. Bernard Bihari discovered LDN enhanced patients' response to infection with HIV, the virus that causes AIDS. Years later he found that his patients with cancer and autoimmune disease also benefited from LDN.
Dr. Bihari has reportedly treated more than 450 cancer patients with LDN with promising results, including cancers of the bladder, breast, liver, lung, lymph nodes, colon, and rectum. According to Dr. Bihari, nearly a quarter of his patients had at least a 75 percent reduction in tumor size, and nearly 60 percent of his patients demonstrated disease stability. He believes LDN's anti-cancer mechanism is likely due to an increase in the:
•Number and density of opiate receptors on the tumor cell membranes, making them more responsive to the growth-inhibiting effects of the already present levels of endorphins, which in turn induces apoptosis (cell death) in the cancer cells
•Absolute numbers of circulating cytotoxic T cells and natural killer cells, as well as killer cell activity
An impressive study released earlier this year exemplifies LDN's potential anti-cancer effects, in this case to treat ovarian cancer.
The study found:
•LDN administered for six hours every two days reduced DNA synthesis and cell replication in tissue culture
•Exposure to LDN in combination with cancer drugs had enhanced anti-cancer action
•Mice with established ovarian tumors treated with LDN had repressed tumor progression by reducing DNA synthesis and angiogenesis -- but not altering cell survival, indicating it is non-toxic
•LDN combined with a chemotherapy drug, cisplatin, alleaviated the toxicity associated with cisplatin
•LDN treatment upregulated the expression of the opioid growth factor, which is the only opioid peptide that tends to inhibit cell growth of ovarian cancer cells
Says Dr. Burton M. Berkson, MD, who has attested to achieving phenomenal results with low-dose naltrexone in both cancer patients and those with autoimmune diseases:
"It is difficult for many to believe that one drug can accomplish so many tasks. But LDN does not treat symptoms as most drugs do. It actually works way "upstream" to modulate the basic mechanisms that result in the disease state."
Your Doctor Probably Doesn't Know About Low-Dose Naltrexone
LDN has been an FDA-approved drug for over two decades, conventionally used to treat drug- and alcohol addiction at doses of 50mg to 300mg. Much lower doses (3 to 4.5 mg) are used for LDN's immunomodulating properties as discussed above, but it has not yet been submitted for FDA approval at this low dose. None of the pharmaceutical giants back it, as at an average price of $15 to $40 for a month's supply, the income potential isn't very promising.
This means there are no friendly sales reps visiting your doctor talking about the potential benefits of this drug in very low doses, and as a result very few physicians are aware of LDN. So, if your physician is not familiar with LDN, you will need to bring it up to him or her, or, alternatively, seek a health care provider who is already knowledgeable at using LDN as a form of treatment. There are a number of pharmacies and compounding pharmacies in the United States and Canada that are reliable sources of the compound in low-dose form.
CAUTION: Important LDN Points to Consider if You Use It
•Avoid slow-release (SR) or timed-release naltrexone. You want to be sure the LDN you receive is in unaltered form that allows you to receive the full dose quickly. Slow-release formulas may not give you the full therapeutic effects.
•Be aware of inactive fillers. Part of the LDN capsule will contain a "neutral" filler material, however there is some evidence to suggest that calcium carbonate as a filler could interfere with the absorption of LDN. So to be on the safe side, avoid LDN capsules that contain calcium carbonate fillers.
Ideally, if you are interested in using LDN as a potential treatment consult with a knowledgeable health care practitioner who can guide your therapy and also help you find a reliable compounding pharmacy.
Source: Eurekalert September 2, 2011
Source: Experimental Biology and Medicine September 1 2011;236(9):1036-50
Related Links:
Could This Powerful Breakthrough Beat Cancer and Auto-Immune Diseases?
Harnessing Your Body's Own Chemistry to Treat Ovarian Cancer
Can LDN Really Help Multiple Sclerosis, Rheumatoid Arthritis and Other Autoimmune Diseases?
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Mirvdl
Joined On 9/2011
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Send Message Posted On Sep 19, 2011
I started LDN over two years ago, with amazing results. I have had MS for 11 years (diagnosed 5 years ago) and observed the ineffectiveness of the conventional MS drugs in other people. I began a very low saturated fat diet five years ago (based on the research of Dr. R. Swank) which kept me from progressing in the disease as long as I experienced little stress in my life. However, when I experienced too much stress, I would have an attack. Then I learned about LDN, and when paired with the Swank diet, I have been able to keep from progressing in the disease, despite stress.
In fact, all the 'fatigue' that comes with MS was gone within a month, and I can exercise daily. You do have to find a doctor to prescribe it--my neurologist wouldn't, but my family doctor did--and a compounding pharmacy who will administer it. The recommended dosage is between 3 and 4.5 mg., and you do need to experiment with the dosage in order to arrive at what is right for you. I'm 5'2" and 103 lbs., so 4.5 mg. was too much for me. I'm currently taking 3.85 mg, and I may be able to go lower. The only side effect is bad dreams or nightmares (which I'm not conscious of at all, but my husband is--when I become startled in my sleep.) Apparently, if you fine tune the dosage enough, these will go away. It cost about $35.00 a month where I live in Canada.
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DLARAH
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Send Message Posted On Sep 20, 2011
MS is caused by a profound feeling of helplessness shock event. If you can identify the time, place and circumstances of this shock, you can resolve this conflict and along with the help you found so far, you can actually cure yourself. Good Luck and here is a helpful website to delve into all kinds of situations in life: http://learninggnm.com .
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therkildsen
Joined On 12/2010
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Send Message Posted On Sep 22, 2011
Feelings? Comon DLARAH, for this particular and serious condition reality is so much more complicated! If only it was that easy. Sadly, the actual cause of MS (multiple sclerosis) is lively debated and it seems to come from many sources. Stress is never good but hardly an actual cause for something this severe. However, there are some factors that statistically show a higher pattern of risk:
• Caucasian are statistically speaking more at risk
• Women are statistically about 1/3 more at risk then men
• To be exposed to some environmental agents PRIOR to adolescence is believed to have an impact on the risk.
• The further away from equator the higher the risk (indicates a deficiency in D Vitamin as a cause)
• Is partly inherited.
• And lastly, some studies indicate that MS can be triggered from a few particular viral infections.
Interesting enough, there are recordings of actual MS “out brakes” which indicates some sort of an environmental hazardous trigger rather than a mere fluke. Not in recent time - to my knowledge though.
All in all, the best advice is to live healthy and be happy – I doubt happiness is a decisive factor, but it certainly does not hurt.
@ Mirvdl, very interesting to hear your experience with LDN. Thank you for sharing.
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bubbabean
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Send Message Posted On Sep 19, 2011
I take it every night. No problems and healthy!!
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Barbara Charis
Joined On 3/2007
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Send Message Posted On Sep 19, 2011
Doctors think Cure...and the use of a substance to block an action. They don't think growth prevention. However, simply not providing any substance that promotes growth in the first place will eliminate tumors.
Twice I have eliminated tumors in my own body by simply eliminating the fuel that contributed to the growth. If tumors don't receive fuel - they won't grow. Nothing grows without a fuel.
In 1976, when I was told by two doctors that I had to have surgery for a rapidly growing tumor...I told the 2nd doctor that I was going to go home and pray...and an answer came. In 2-1/2 months I went back to the doctor to show him that it was gone - and he wasn't one bit interested in what I did. He attributed it to "spontaneous remission."
In 1988 I didn't even bother going to a doctor, when I had an ugly bulbous growth with spikes coming out of it on my chest. I simply asked myself, what I did to make it grow. It was amazing to discover that the excessive amount of raw honey that I had been using in my herb tea was was the cause. I didn't realize how much I was using, until this growth occurred. I was using about 5 lbs of honey, every three weeks. Excessive carbs, excessive protein and excessive fat can all provide fuel for the growth of tumors.
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VonSchneider
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Send Message Posted On Sep 21, 2011
Thanks for sharing.
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alanschachter
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Send Message Posted On Sep 19, 2011
Here is the clinical trial results for LDN & Crohn's. Very impressive, showing 78% with significant improvement. ***ldncrohns And LDN works even better when combined with a gluten/soy/casein restricted diet like Paleo.
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enjonn
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Send Message Posted On Sep 19, 2011
This article promotes Low-Dose Naltrexone, a pharma product. Very clearly, Dr. Mercola, you are pro-health rather than anti-pharma. Cheers!
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mohammad kazemi
Joined On 11/2006
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Send Message Posted On Sep 19, 2011
Amen. I also think that there might be some benefits to some individuals from Metformin
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Shasha
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Send Message Posted On Sep 19, 2011
LDN is awesome....goes down like a vitamin...it is like a miracle. It is not like other drugs...has no sideeffects except that I had to drink more water. LDN is needed by millions along with Celiac help...eating no gluten/dairy/soy/sugar and taking vitamins/good oils.
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Margaux
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Send Message Posted On Sep 19, 2011
It is working for me for rheumatoid arthritis like symptoms in my hand, pain swelling stiffness. I am functional again. It took 3 months to take full effect. Thank goodness.
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LDNadvocate
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Send Message Posted On Sep 21, 2011
My husband has used nothing but LDN (4.5mg nightly) for his MS for six and a half years. After doing plenty of research after receiving his diagnoses, we decided to give LDN a try and luckily his neuro was open to it. It is truely an amazing drug, non toxic, affordable and has certainly slowed down the progression of the disease. My husband has had no new lesions appear on his annual MRI and no drastic evidence of disease progression. He rarely gets sick and his bloodwork is all good each year.
LDN combined with attention to diet and lifestyle may be the best thing anyone can do for their disease. My husband will happily take it forever!
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cogitate
Joined On 11/2007
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Send Message Posted On Sep 19, 2011
Can low dose Naltrexone be used in combination with DCA? Why do most patients who achieve remission on LDN seem to relapse if they then discontinue the LDN, (according to Dr. Bihari's observations per the LDN site)?Thanks for any answer offered.
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jamdenison
Joined On 11/2009
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Send Message Posted On Sep 19, 2011
Probably because this is somehow like a nutrient rather than a drug. It is just something the body needs to promote the immune system. I will definitely be asking my mom's doctor to put her on this. Cheap AND healing. Perfect. She just had another blood test and while her protein M was at an acceptable low level on one protein electrophoresis, another showed still a slight spike in an immunoglobulin, so maybe it will bring that down and she won't need Velcade at $2,000 per IV! Yeah. Thanks sooo much for finding this Dr. M. You know this will be the next question for her oncologist. Perfect.
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Margaux
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Send Message Posted On Sep 19, 2011
As I understand it you have beta endorphin receptors on your immune cells - you need the beta endorphins to activate the immune cells. If you don't have active immune cells you get all sorts of diseases. The LDN stops the beta endorphins for a short while and then your body compensates by making a lot of beta endorphins. (The regular dose 50mg stops the beta endorphins completely.) So unless your body starts making more beta endorphins by itself this is the only way I know to get more. That is why your immune cells don't work as well when one stops taking LDN and why the symptoms come back.
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Shasha
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Send Message Posted On Sep 19, 2011
LDN blocks Celiac...gluten/dairy/soy/sugar make the immune system go down. LDN stops the immune system going down from the food. If the person keeps eating the food the cancer can come back. LDN is for life...unless they eat so well they can prevent the immune system from going down. LDN helps block contamination issues of gluten/dairy.
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LDNadvocate
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Send Message Posted On Sep 21, 2011
You do need to continue taking LDN in order to slow down/stop the disease progression.
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evercafe
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Send Message Posted On Sep 19, 2011
with a 75% tumor size reduction in almost 25% of certain cancer patients .... very imppressive for such a gentle drug ...however, likely only a 2% complete cancer cure rate !!! so, i would definitely still be looking for other means to effect a cure !
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regriasregalia
Joined On 11/2010
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Send Message Posted On Sep 19, 2011
okay so I just read about the drug naltrexone (ldn)that helps you heal your body. Is there a list of places that have physicians or pharmacies that do support this and where I can get it. I live in Wisconsin.
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Mr.Wizard
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Send Message Posted On Sep 19, 2011
First, check with your healthcare provider to make sure LDN will not adversely interact with other medications you may be taking. Once you have a prescription, use the internet to search for a "compounding pharmacy" that has experience dealing with LDN. If you search for "compounding pharmacies in Wisconsin," I'm sure you'll get lots of hits. Good luck!!
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regriasregalia
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Send Message Posted On Sep 19, 2011
Thank you for the information "Mr. Wizard." Well appreciated.
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VonSchneider
Joined On 6/2010
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Send Message Posted On Sep 21, 2011
Don't let poo-pooers stop you. You could try blog groups or support groups of those who may be using LDN, and ask them. People often do not want to insult their doctors or go against their doctor's "infinite wisdom". If your doctors are not willing to help you, then they are NOT doing what you pay them to do. So look elsewhere, what you intend is "looking for you". Good luck.
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Mr.Wizard
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Send Message Posted On Sep 19, 2011
Research shows that LDN benefits Type 1 diabetics too!!
Read more here: www.lowdosenaltrexone.org
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live4surf
Joined On 8/2011
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Send Message Posted On Sep 19, 2011
Mr. Wizard, I looked all over the link you provided, but didn't see any reference to Type 1 diabetes. Where is it? Thanks.
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Mr.Wizard
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live4surf:
When you go to the link, read down under the "Background section." Type 1 diabetes is mentioned in the context of being an autoimmune disease and the benefits of LDN for autoimmune diseases.
Also, here's another list of health conditions that LDN "will" or "may" have a beneficial effect on. Type 1 and Type 2 diabetes are both listed under "may" have an effect on. Hope this helps!
http://www.fiikus.net/?ldn
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Mr.Wizard
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live4surf:
Here's another link to the announcement of a clinical trial looking at whether LDN may be effective in treating Type 1 diabetes.
cureresearch4type1diabetes.blogspot.com/2010_06_01_archive.html
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live4surf
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Send Message Posted On Sep 19, 2011
Mr. Wizard: Thank you so much for the helpful information in the links!
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Shasha
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LDN helps any health issue caused by Celiac. LDN helps to block Celiac...but the Celiac diet is still needed since you can override the medicine with what you eat. Not eating gluten/dairy/soy/sugar...taking vitamins/good oils is also needed. LDN may help these health issues that Celiac causes:Celiac person may get one or more of the following: failure to thrive, tired, sad, sensitive/cry alot, learning disabilities, Autism, Attention deficient, hyperactive, wet pants, ear infections, food allergies due to leaky gut, stomach ache, eczema, diarrhea, constipation, gas, bloating, IBS, lactose intolerance, eating disorders, yeast, asthma, overweight (crave dairy/gluten/sugar)....., depression, anxiety, PTSD, panic attacks, suicidal, sleeping problems, obsessions, drug use, cigarette use, alcoholism (crave gluten in the alcohol), addictions, short height, hair loss,.... bipolar, schizophrenia, seizures, gall/kidney stones, endometriosis, PCO disease, infertility problems, thyroid problems, Chronic fatigue, psorasis, acid reflex (heart burn), ulcers, premature gray hair, swollen joints, arthritis....Diabetes, Fibromyalgia, Non-Hodgkin's lymphoma, Cancer, MS, Crohn's disease, Lupus, Osteoporosis, high blood pressure, hormone problems, dementia, heavy metals, Alzheimers, die young and more... for which Celiac maybe the root cause.
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VonSchneider
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Send Message Posted On Sep 21, 2011
I agree Shasha.
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Har_Don
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Send Message Posted On Sep 19, 2011
I'm so excited to see Dr. M talk about this drug. I've never heard of it before, but I am diabetic, and I do have neuropathy. I visit my Dr. again on Friday. I will definitely be asking him about this. Thank you all so much for your comments. They have really encouraged me to try and find this drug.
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Pax et Veritas
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Send Message Posted On Sep 19, 2011
I'd be curious if this drug could be safe and effective for dogs. My dog possibly has myositis, an autoimmune disease effecting the muscles. Does anyone know if it's been tested on dogs?
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Alioops
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Send Message Posted On Sep 19, 2011
That would be a great question for Dr. Becker. Look under PETS at the top of this page and it should link you to her page. Good luck.
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Shasha
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Send Message Posted On Sep 19, 2011
If the dog get gluten/dairy/soy/sugar free food it may help him. I get Pure Vita food for my cats...it is gluten free.
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LDNadvocate
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Plenty of dogs are given LDN with a lot of sucess. If you contact Skips Pharmacy in Florida (google for contact info) they are very knowledgable with treating dogs with LDN - very helpful staff. You will still need to get a script from your vet but Skips can advise on what dose to give and can compound it for you.
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DLARAH
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Send Message Posted On Sep 20, 2011
Some cancers do not manifest cell proliferation but cell degeneration and some manifest a loss of feeling.
The point I want to make is: anything the body can use to heal itself is helpful, but sometimes the special program of Nature just needs to be recognized and delt with appropriately for healing to progress.
http://learninggnm.com .
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Sparta
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Can this be given to an FIV+ cat?
(I will ask this question on Dr. Becker's forum as well.)
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Pax et Veritas
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I didn't see anything on Healthy Pets. I wlpa "s hoping Dr. Mercola knew something.
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Julia Schopick
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Send Message Posted On Sep 20, 2011
Dr. Mercola:
I'm so glad to see this article about Low Dose Naltrexone (LDN). It is a treatment I have been passionate about ever since I started researching it for my Amazon.com best-selling book, "HONEST MEDICINE: Effective, Time-Tested, Inexpensive Treatments for Life-Threatening Diseases." LDN is one of the four life-saving treatments I profile in my book. The others are: Intravenous Alpha Lipoic Acid, for liver disease and, with LDN, for some very serious cancers; the Ketogenic Diet for pediatric epilepsy; and Silverlon for non-healing wounds.
I am honored that Dr. Burt Berkson, who is also featured in my book, has not only contributed a chapter; he has also written the preface. And Dr. Bihari's widow, Jacqueline Young, has written a magnificent testimonial, which can be found in the beginning of the book.
Again, thanks so much for writing about LDN. It is so inexpensive AND effective, and it is so helpful for so many conditions, that I really believe LDN -- and the other treatments I write about -- could save healthcare. We need inexpensive, effective treatments like these.
Julia Schopick
HonestMedicine.com
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eefwylie
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Send Message Posted On Sep 21, 2011
I'm a "healthy" 53 year old woman who takes LDN. I did have a seasonal asthma type cough which also I had in the mornings on rising. (Non smoker). This cough has GONE! I put my son 21 years old on LDN for Fibromyaglia and he has had improvements and copes with relatively normal life now! I've put my Mother on this and her twin sister. Both have M.E./CFS/FMS and have had improvements especially my Mother. I love LDN and would like to see everyone take it! Its the best! Don't take anything besides LDN and nor does my son!
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VonSchneider
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Send Message Posted On Sep 21, 2011
Have you also tried the diet changes suggested here? If diet were the cause of the issue, diet alone may cure these issues. While LDN is great and may help many people; people do not have an inborn LDN deficiency. If you are giving your body the wrong fuel, problems may arrise. I appreciate your enthusiasm, but body's don't make coughs and fibromyalgia for no reason. Could be a relatively simple fix, like eliminating grains, fructose, milk, artificial sweetners, ect. I wish you well. As Dr, Mercola has stated, could be mold???
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