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Nat Genet. 2012 Oct 29;44(11):1174-6. doi: 10.1038/ng.2448.

Older males beget more mutations.

Hurles M.

Source

The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

Abstract

Three papers characterizing human germline mutation rates bolster evidence for a relatively low rate of base substitution in modern humans and highlight a central role for paternal age in determining rates of mutation. These studies represent the advent of a transformation in our understanding of mutation rates and processes, which may ultimately have public health implications.