Summary: Age of the biological father.

Summary: Age of the biological father.
Webpages
1.mock exam | genetics
ome.umaryland.edu/AcademicD/practiceExams/genetics/Genetics. ...
2.elsi - human genome project
www.kumc.edu/gec/prof/geneelsi.html
3.dna repair activity linked to paternal age effect
www.uthscsa.edu/opa/issues/new33-32/graduate.htm
4.when to seek genetic counseling
www.childrens.com/HealthLibrary/HealthLibContent.cfm?pageid= ...
5.study of aneuploidy in normal and abnormal germ cells from semen of fertile and infertile men
www.tecnobiosprocreazione.it/en/published-papers/study-of-an ...
6.study of aneuploidy in normal and abnormal germ cells from semen of fertile and infertile men
www.tecnobiosprocreazione.it/pubblicazioni-scientifiche/stud ...
7.when to seek genetic counseling - children's hospital of philadelphia
www.chop.edu/consumer/your_child/condition_section_index.jsp ...
8.when to seek genetic counseling - children's hospital of philadelphia
www.chop.edu/consumer/your_child/condition_section_index.jsp ...
9.mount sinai - achondroplasia
www.mountsinai.org/Other/Diseases/Achondroplasia
10.university of medicine and dentistry of nj: news events
www.umdnj.edu/about/news_events/releases/06/r051006_birth_we ...
Research Grants
1.Male Mutation Bias and Paternal Age Effect in Mammals
Kateryna Makova; Fiscal Year: 2009
2.Mentoring Translational Schizophrenia Researchers
Dolores Malaspina; Fiscal Year: 2007
3.Mentoring Translational Schizophrenia Researchers
Dolores Malaspina; Fiscal Year: 2006
4.Jerusalem Perinatal Cohort Schizophrenia Study II
Dolores Malaspina; Fiscal Year: 2009
5.Epigenetic Mechanisms: Paternal Age and Neural Function
Jay Gingrich; Fiscal Year: 2006
6.A Genomic Approach to Studying Repeat Instability in Schizophrenia
DIANE DICKEL; Fiscal Year: 2007
7.Negative Symptoms of Schizophrenia: From Phenomenology to Targeted Treatment
Arielle Stanford; Fiscal Year: 2007
8.Prenatal Factors and Risk of Bipolar Disorder
Alan Brown; Fiscal Year: 2009
9.Biodemography of Exceptional Longevity in the United States
Leonid Gavrilov; Fiscal Year: 2009
10.PATERNAL EXPOSURE AND SPORADIC BILATERAL RETINOBLASTOMA
Greta Bunin; Fiscal Year: 2005
Publications
1. Birth weight and melanoma risk: a population-based case-control study
I Franco Lie
Department for Research and Education, Center for Clinical Research, Ullevaal University Hospital, Oslo 0407, Norway
Br J Cancer 98:179-82
2. Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States)
Shu Xiao Ou
Department of Pediatrics, University of Minnesota, Minneapolis, USA
Cancer Causes Control 13:15-25
3. Offspring birthweight is not associated with paternal insulin resistance
B Knight
Diabetes and Vascular Medicine, Peninsula Medical School, Barrack Road, Exeter EX2 5DW, UK
Diabetologia 49:2675-8
4. Targeted prenatal herpes simplex virus testing: can we identify women at risk of transmission to the neonate?
Karen E Mark
Department of Medicine, University of Washington, Seattle, WA, USA
Am J Obstet Gynecol 194:408-14
5. Fathers over 40 and increased failure to conceive: the lessons of in vitro fertilization in France
Elise de La Rochebrochard
INED, Le Kremlin Bicêtre, F 94276, France
Fertil Steril 85:1420-4
6. Risk factors for first trimester miscarriage--results from a UK-population-based case-control study
N Maconochie
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
BJOG 114:170-86
7. Down syndrome, paternal age and education: comparison of California and the Czech Republic
Dagmara Dzurova
Faculty of Science, Charles University, Czech Republic
BMC Public Health 5:69
8. Grandparents' age and the risk of Down's syndrome in Norway
Method R Kazaura
Centre for International Health, Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
Acta Obstet Gynecol Scand 85:236-40
9. Parental age difference and adverse perinatal outcomes in the United States
Wendy L Kinzler
Department of Obstetrics, Gynecology and Reproductive Sciences, UMDNJ Robert Wood Johnson Medical School Saint Peter s University Hospital, New Brunswick, NJ 08903 0591, USA
Paediatr Perinat Epidemiol 16:320-7
10. The effect of parental race on fetal and infant mortality in twin gestations
Hongzhuan Tan
OMNI Research Group, Department of Obstetrics and Gynecology, University of Ottawa, Faculty of Medicine, Ottawa, Canada
J Natl Med Assoc 96:1337-43 Scientific Experts
D Malaspina
Paola Astolfi
Method Kazaura
James F Crow
R John Aitken
D K L Cheuk
H Kokko
Stanley Zammit
Shi Wu Wen
R Slama
K Kleinhaus
Nancy E Reichman
J Cohen
M Bessin
Ida N Damgaard
K Sol-Church
Mark A Baker
Christina M Gibson-Davis
S Odent
Dagmara Dzurova
Isabelle Bray
Gábor Vogt
A K Ludwig
Abraham Reichenberg
C Deighton
D Kim Waller
Daniel Bodri
Jorge López Castromán
Armand Zini
Lan T Vu
Elizabeth Whitehead
Claudine Sauvain Dugerdil
O Oneko
Saroja Krishnaswamy
Emma M Frans
Stephen A Brown
D P Mukherjee
Fei Xue
J Rosenbauer
Julio Nazer
Fang Fang
Liesbeth Steenhof
Marie Vandresse
Anshu Shrestha
Camilla Bille
I Labadaridis
R H Martin
N Simon Thomas
Vorasuk Shotelersuk
Ariane Kemkes-Grottenthaler
Anne-Marie Nybo Andersen
James W Collins
Ann E Pulver
H Korpelainen
Valma Harjutsalo
Lisa A Croen
John J McGrath
M Weiser
Vincent Duindam
Mogens Vestergaard
Helene Verdoux
Kerstin Strömland
Alan S Brown
Linlea Armstrong
C Fridman
Helga V Toriello
B Littorin
Mohamed Aboulghar
W J Millar
M Vekemans
Nicholas K Priest
John Mirowsky
Katariina Hannula
Michaeline Bresnahan
Jean-Marie Robine
Marie I Cedergren
C A Walter
N Maconochie
Wendy L Kinzler
Leonid A Gavrilov
Lorenzo Richiardi
Xiaomei Ma
P Shah
Greta Bunin
Kateryna Makova
Trace Kershaw
Brian Kirkpatrick
DIANE DICKEL
Arielle Stanford
Jennifer St Sauver
Detail Information
Research Grants52
1.Male Mutation Bias and Paternal Age Effect in Mammals
Kateryna Makova; Fiscal Year: 2009
..in males than in females (male mutation bias) and higher mutation rate in older males than in younger males (paternal age effect)...
2.Mentoring Translational Schizophrenia Researchers
Dolores Malaspina; Fiscal Year: 2007
..She published a series of papers establishing advanced paternal age as a major risk factor for schizophrenia and demonstrated that olfactory processing and social capacity, known ..
3.Mentoring Translational Schizophrenia Researchers
Dolores Malaspina; Fiscal Year: 2006
..She published a series of papers establishing advanced paternal age as a major risk factor for schizophrenia and demonstrated that olfactory processing and social capacity, known ..
4.Jerusalem Perinatal Cohort Schizophrenia Study II
Dolores Malaspina; Fiscal Year: 2009
..96 percent by age 34. We made seminal findings on the relationship of SCZ to paternal age, since replicated by many groups, and showed effects of circumscribed prenatal stress on the risks for SCZ and ..
5.Epigenetic Mechanisms: Paternal Age and Neural Function
Jay Gingrich; Fiscal Year: 2006
..question is of critical interest since several complex behavioral disorders arise in offspring in proportion to paternal age at the time of conception. These include schizophrenia, mental retardation, and Alzheimer's disease...
6.A Genomic Approach to Studying Repeat Instability in Schizophrenia
DIANE DICKEL; Fiscal Year: 2007
..Repeat expansions are potentially intriguing in schizophrenia given the disorder's neurological phenotype, paternal age bias, and possible anticipation...
7.Negative Symptoms of Schizophrenia: From Phenomenology to Targeted Treatment
Arielle Stanford; Fiscal Year: 2007
..symptoms, including the division of patients into Deficit Syndrome (DS) and nonDS groups, and data supporting Paternal Age Related Schizophrenia (PARS) as an independent variant...
8.Prenatal Factors and Risk of Bipolar Disorder
Alan Brown; Fiscal Year: 2009
....
9.Biodemography of Exceptional Longevity in the United States
Leonid Gavrilov; Fiscal Year: 2009
....
10.PATERNAL EXPOSURE AND SPORADIC BILATERAL RETINOBLASTOMA
Greta Bunin; Fiscal Year: 2005
..The mutation data will be used with the exposure data to test hypotheses that ionizing radiation and older paternal age are risk factors for specific types of mutation. The study will use a matched case-control design with 250pairs...
11.Prenatal diagnosis through selective DNA amplification
Stephen Brown; Fiscal Year: 2009
..When and if such methods become available, they will revolutionize prenatal diagnosis and will represent a major milestone in the improvement of prenatal care. ..
12.Prenatal Exposure to Polyfluoroalkyl Compounds in the EMA Study
Lisa Croen; Fiscal Year: 2009
..In the long-term, a better understanding of the underlying biology may suggest appropriate strategies for early intervention and contribute to the eventual prevention of this often devastating and usually life-long disability. ..
13.HETEROGENEITY OF BIPOLAR DISORDER
Ann Pulver; Fiscal Year: 2003
....
14.Prenatal Factors and Risk of Schizophrenia in a Finnish National Birth Cohort
Alan Brown; Fiscal Year: 2009
..Moreover, the research described in this proposal has future potential for the identification of susceptibility genes that interact with the prenatal exposures and other developmental antecedents in the etiology of schizophrenia. ..
15.Randomized Controlled Trial to Enhance Dual Protection Among PLHIV in India
Trace Kershaw; Fiscal Year: 2009
....
16.CONTROL SELECTION METHODS FOR CHILDHOOD CANCER STUDIES
Greta Bunin; Fiscal Year: 2009
..A feasible and valid control group is needed to ensure that studies of childhood cancer are scientifically valid and therefore, will provide results that can eventually lead to prevention of these cancers. ..
17.MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIA
Ann Pulver; Fiscal Year: 2007
..abstract_text> ..
18.Effect of Suppressive Therapy on Behavioral Determinants of HSV-2 Transmission
KAREN MARK; Fiscal Year: 2007
....
19.Identifying Mechanisms for Chromosome 21 Nondisjunction
Tiffany Oliver; Fiscal Year: 2007
..We will use a modified tetrad analysis to infer the exchange pattern from the observed recombination data. ..
20.Occupational Pesticide Exposure of Parents and Brain Tumor Risk in Children
Greta Bunin; Fiscal Year: 2007
..The assessment of job tasks has been used little or not at all in studies of occupational exposure and childhood cancer. The proposed study will provide information on the usefulness of these approaches. ..
21.Prenatal and Neonatal Biologic Markers for Autism
Lisa Croen; Fiscal Year: 2006
..abstract_text> ..
22.Diabetes in Neuropsychiatric Disorders
Brian Kirkpatrick; Fiscal Year: 2009
..These studies will assess whether schizophrenia is associated with impaired glucose tolerance, and whether this abnormality predicts the subsequent risk of impaired fasting glucose with olanzapine administration. ..
Publications124 found, 100 most recent shown here
1. Birth weight and melanoma risk: a population-based case-control study
I Franco Lie
Department for Research and Education, Center for Clinical Research, Ullevaal University Hospital, Oslo 0407, Norway
Br J Cancer 98:179-82
..The adjusted OR was 0.81 (95% CI: 0.52-1.26) for birth weight below 2500 g (exposed). Though not statistically significant, the results suggest that low birth weight might influence the risk of melanoma later in life...
2. Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States)
Shu Xiao Ou
Department of Pediatrics, University of Minnesota, Minneapolis, USA
Cancer Causes Control 13:15-25
..young maternal age (<20 compared to 25-29, OR = 1.4, 95% CI = 1.1-1.9), advanced paternal age (>39 compared to 25-29, OR = 1.4, 95% CI = 1.0-1.9), induced abortion prior to the index pregnancy (OR = 1...
3. Offspring birthweight is not associated with paternal insulin resistance
B Knight
Diabetes and Vascular Medicine, Peninsula Medical School, Barrack Road, Exeter EX2 5DW, UK
Diabetologia 49:2675-8
..CONCLUSIONS/INTERPRETATION: Results from a young, adult, non-diabetic population do not support the foetal insulin hypothesis as an explanation for the association of low birthweight with insulin resistance...
4. Targeted prenatal herpes simplex virus testing: can we identify women at risk of transmission to the neonate?
Karen E Mark
Department of Medicine, University of Washington, Seattle, WA, USA
Am J Obstet Gynecol 194:408-14
..9, 95% CI 1.1-3.3) and paternal age younger than 20 years or unknown (aOR = 1.7, 95% CI 0.7-3.7)...
5. Fathers over 40 and increased failure to conceive: the lessons of in vitro fertilization in France
Elise de La Rochebrochard
INED, Le Kremlin Bicêtre, F 94276, France
Fertil Steril 85:1420-4
OBJECTIVE: To investigate paternal age effect mediated by biological modifications with use of data from assisted reproductive technologies. DESIGN: National IVF registry. SETTING: Fifty nine French IVF centers...
6. Risk factors for first trimester miscarriage--results from a UK-population-based case-control study
N Maconochie
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
BJOG 114:170-86
..high alcohol consumption; feeling stressed (including trend with number of stressful or traumatic events); high paternal age and changing partner...
7. Down syndrome, paternal age and education: comparison of California and the Czech Republic
Dagmara Dzurova
Faculty of Science, Charles University, Czech Republic
BMC Public Health 5:69
..However, the effect of paternal age and education of parents has not been frequently studied. Comparative studies on Down syndrome are also rare...
8. Grandparents' age and the risk of Down's syndrome in Norway
Method R Kazaura
Centre for International Health, Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
Acta Obstet Gynecol Scand 85:236-40
..There are also several studies of a possible effect of paternal age, but no consistent evidence of an association is found...
9. Parental age difference and adverse perinatal outcomes in the United States
Wendy L Kinzler
Department of Obstetrics, Gynecology and Reproductive Sciences, UMDNJ Robert Wood Johnson Medical School Saint Peter s University Hospital, New Brunswick, NJ 08903 0591, USA
Paediatr Perinat Epidemiol 16:320-7
..This demonstrates that race and maternal age both contribute to the effects of parental age difference on adverse perinatal outcomes...
10. The effect of parental race on fetal and infant mortality in twin gestations
Hongzhuan Tan
OMNI Research Group, Department of Obstetrics and Gynecology, University of Ottawa, Faculty of Medicine, Ottawa, Canada
J Natl Med Assoc 96:1337-43
..19-1.58) and lowest for W-W. Thus, twin infants born to black parents have higher risk of fetal and infant mortality compared with twin infants born to white parents and infants of mixed race parents generally have intermediate outcomes...
11. Obstetric complications and breast feeding in schizophrenia
Mario Amore
Institute of Psychiatry, University of Parma, p. le Matteotti 9, 43100 Parma, Italy
J Nerv Ment Dis 190:705-7
12. Loss of a child and the risk of amyotrophic lateral sclerosis
Fang Fang
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Am J Epidemiol 167:203-10
..5, 95% CI: 0.3, 0.8) than loss due to other causes. These data indicate that the risk of developing ALS decreases following the severe stress of parental bereavement. Further studies are needed to explore potential underlying mechanisms...
13. Down's syndrome and paternal age in Norway
Method R Kazaura
Centre for International Health, Section for Medical Statistics, University of Bergen, Bergen, Norway
Paediatr Perinat Epidemiol 16:314-9
There is strong evidence for an effect of maternal age on the risk of Down's syndrome. An effect of paternal age has been suspected, but so far neither confirmed nor completely excluded...
14. Case-control study of parental age, parity and socioeconomic level in relation to childhood cancers
J D Dockerty
Childhood Cancer Research Group, Department of Paediatrics, University of Oxford, 57 Woodstock Road, Oxford OX2 6HJ, UK
Int J Epidemiol 30:1428-37
..The strong ALL association with parity may be because of an unknown environmental risk factor...
15. Influence of advanced age of maternal grandmothers on Down syndrome
Suttur S Malini
Human Genetics Laboratory, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore 570 006, India
BMC Med Genet 7:4
..CONCLUSION: Besides the known risk factors, mother's age, father's age, the age of the maternal grandmother at the time of birth of the mother is a risk factor for the occurrence of Down syndrome...
16. Boy/girl differences in risk for reading disability: potential clues?
J L St Sauver
Department of Health Sciences Research, Section of Clinical Epidemiology, Mayo Clinic Rochester, Rochester, MN 55905, USA
Am J Epidemiol 154:787-94
..28, 95% CI: 1.59, 3.27). Boys and girls appear to be differentially susceptible to RD risk factors, suggesting that the biologic processes leading to RD may differ between boys and girls...
17. Clinical characteristics and survival of trisomy 18 in a medical center in Taipei, 1988-2004
Hsiang-Yu Lin
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
Am J Med Genet A 140:945-51
..When prenatal or postnatal decisions need to be made, the possibility of long-term survival should be included in any discussion to enable families to make the most appropriate decision...
18. Births: final data for 2004
Joyce A Martin
Division of Vital Statistics, Centers for Disease Control and Prevention, National Center for Health Statistics, Hyattsville, MD 20782, USA
Natl Vital Stat Rep 55:1-101
..Preterm and low birthweight rates continued their steady rise. The twinning rate increased, but the rate of triplet and higher order multiple births was down slightly...
19. Prediction of intra-twin birth weight discordance by binary logistic regression analysis
Shi Wu Wen
School of Public Health, Central South University, Changsha, Hunan, PR China
Gynecol Obstet Invest 62:186-92
..8%, respectively, at the cut-off value of 0.09 in group 2. CONCLUSION: A birth weight discordance prediction model that includes seven variables available during pregnancy has been established with acceptable diagnostic performance...
20. Effects of maternal and paternal age on Caucasian and Native American preterm births and birth weights
Ernest L Abel
Department of Obstetrics and Gynecology, C.S. Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan, USA
Am J Perinatol 19:49-54
The purpose of this study was to compare the effects of maternal and paternal age on Native American and Caucasian infants. Data were abstracted from birth records compiled in North Dakota from 1978 to 1992...
21. Estimation of a structural model of the determinants of neonatal mortality in Hungary, 1984-88 and 1994-98
Marie Vandresse
Université Catholique de Louvain, Louvain la Neuve, Belgium
Popul Stud (Camb) 62:85-111
..Father's age has no direct or indirect causal effect on neonatal mortality...
22. Comparative birth weights of singletons born after assisted reproduction and natural conception in previously infertile women
C de Geyter
Women s Hospital and Department of Research, University of Basel, Basel Switzerland
Hum Reprod 21:705-12
..Freezing and thawing of oocytes in the pronucleate stage had a lesser impact on pregnancy span and on neonatal birth weight...
23. Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm
Masayuki Kimura
The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jeresey, United States of America
PLoS Genet 4:e37
..We explored the relation between paternal age and offspring's LTLs in 4 different cohorts...
24. Prediction of small for gestational age by logistic regression in twins
Shi Wu Wen
School of Public Health, Central South University, Changsha, China
Aust N Z J Obstet Gynaecol 45:399-404
..CONCLUSIONS: A prediction model based on determinants that can be obtained at early gestation might be useful in the management of pregnancies with high risk of SGA in twins...
25. Births: final data for 2005
Joyce A Martin
Division of Vital Statistics, U S Department of Health and Human Services, National Center for Health Statistics, Centers for Disease Control and Prevention, National Vital Statistics System, Hyattsville, MD 20782, USA
Natl Vital Stat Rep 56:1-103
..Preterm and low birthweight rates also continued to rise; the twin birth rate was unchanged and the rate of triplet and higher order multiple births declined for the 7th consecutive year...
26. Paternal age and congenital malformations
Jin Liang Zhu
The Danish Epidemiology Science Centre, University of Aarhus, Denmark
Hum Reprod 20:3173-7
BACKGROUND: Spontaneous mutations in germ cells increase with male age, but an association between paternal age and congenital malformations is not well established...
27. Sudden infant death syndrome in Canada: trends in rates and risk factors, 1985-1998
I D Rusen
Health Surveillance and Epidemiology Division, Centre for Healthy Human Development, Health Canada, Ottawa, Ontario, Canada
Chronic Dis Can 25:1-6
..However, the lack of reliable risk factor data limits the extent to which the decline can be attributed directly to the campaign...
28. Early life risk factors for attention-deficit/hyperactivity disorder: a population-based cohort study
Jennifer L St Sauver
Division of Epidemiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
Mayo Clin Proc 79:1124-31
..In addition, boys born to parents with low maternal and paternal education levels appear to be at an increased risk for ADHD compared with girls born to parents with low education levels...
29. Advanced paternal age and risk of fetal death: a cohort study
Anne Marie Nybo Andersen
Department of Social Medicine, University of Copenhagen, Copenhagen, Denmark
Am J Epidemiol 160:1214-22
A possible detrimental paternal age effect on offspring health due to mutations of paternal origin should be reflected in an association between paternal age and fetal loss...
30. Differing intergenerational birth weights among the descendants of US-born and foreign-born Whites and African Americans in Illinois
James W Collins
Department of Pediatrics, Children s Memorial Hospital, Northwestern University Medical School, Chicago, IL 60614, USA
Am J Epidemiol 155:210-6
..The authors conclude that the expected intergenerational rise in birth weight does not occur among the direct female descendants of foreign-born African-American women...
31. Early nutrition and risk of Type 1 diabetes mellitus--a nationwide case-control study in preschool children
J Rosenbauer
German Diabetes Clinic, German Diabetes Centre, Leibniz Centre at the Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40221 Düsseldorf, Germany
Exp Clin Endocrinol Diabetes 115:502-8
..Our findings indicate that infant feeding is causally associated with type 1 diabetes risk and that a considerable part of new type 1 diabetic cases is potentially preventable...
32. Geographic variations in possible risk factors for severe cardiac malformations
M Cedergren
Department of Health and Environment, Faculty of Health Sciences, Linköping University, Sweden
Acta Paediatr 91:222-8
..childlessness, maternal disease, body mass index, medical drug use, alcohol use, parental employment, paternal age, and urban/rural residency...
33. Parent's age and the risk of oral clefts
Camilla Bille
Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winsløwsvej 9, DK 5000 Odense C, Denmark
Epidemiology 16:311-6
..The aim of this study is to determine the degree to which maternal age and paternal age independently influence the risk of having a child with oral clefts...
34. Cytogenetic profile of Down syndrome in Alexandria, Egypt
M M Mokhtar
Department of Human Genetics, Medical Research Institute, University of Alexandria, Alexandria, Egypt
East Mediterr Health J 9:37-44
..2 years) but not in translocation (25.3 years). There was an excess of males in all groups except the mosaic group where the male:female ratio was 0.67. Cytogenetic investigations assist in patient management and family counselling...
35. [Increasing rates of Down syndrome among newborns in Chile from 1972 to 2005]
Julio Nazer H
Unidad de Neonatología, Hospital Clínico, Universidad de Chile, Santiago de Chile
Rev Med Chil 134:1549-57
..001. CONCLUSIONS: The rates of newborns with Down syndrome increased in the period 1972-2005, bearing a close relationship with the increase in maternal ages...
36. Live birth prevalence of Down syndrome in Tottori, Japan, 1980-1999
Ariko Takeuchi
Watanabe Hospital, Tottori, Japan
Am J Med Genet A 146:1381-6
....
37. Association of early life factors and acute lymphoblastic leukaemia in childhood: historical cohort study
L Murray
Northern Ireland Cancer Registry, Department of Epidemiology and Public Health, The Queens University, Belfast, Riddel Hall, Stranmillis Road, Belfast BT9 5EE, UK
Br J Cancer 86:356-61
..Multivariable analyses showed a positive association between high paternal age (> or =35 years) and acute lymphoblastic leukaemia (relative risk=1.49; 95% confidence interval (CI)=0.96--2...
38. Control selection strategies in case-control studies of childhood diseases
Xiaomei Ma
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
Am J Epidemiol 159:915-21
..0% for 560 enrolled birth certificate controls), using birth records to recruit controls appears to provide a representative sample of children and an opportunity to assess the representativeness of controls...
39. [Frequency of multiple neonatal malformations in Pelotas, Rio Grande do Sul, Brazil, and associated socio-demographic factors]
Martha Lopes Schuch de Castro
Faculdade de Ciências Biológicas, Universidade Católica de Pelotas, Pelotas, Brazil
Cad Saude Publica 22:1009-15
..Significant results were found for birth weight, twin births, parents' ethnic background, paternal age, and number of previous abortions and stillbirths...
40. Survival with trisomy 18--data from Switzerland
D Niedrist
Institute of Medical Genetics, University of Zurich, Zurich, Switzerland
Am J Med Genet A 140:952-9
..In more than 50% genital hypoplasia was also described. We further analyzed survival of live-borns in relation to the length of gestation and to VSD and esophageal atresia...
41. Births: final data for 2003
Joyce A Martin
US Department of Health and Human Services, Centers for Disease Prevention, National Center for Health Statistics, Hyattsville, MD, 20782, USA
Natl Vital Stat Rep 54:1-116
..Key measures of birth outcome-the percentages of preterm and low birthweight (LBW) births-rose. The twinning rate increased, but the rate of triplet and higher order multiple births was essentially stable...
42. Factors influencing initiation of breast-feeding among urban women
Lawrence Noble
Department of Pediatrics, Jacobi Medical Center, Bronx, New York 10461, USA
Am J Perinatol 20:477-83
..Significantly more multiparas decided prior to the pregnancy compared with primaparas. We recommend that breast-feeding education should be started prior to the first pregnancy and tailored to the concerns of the women...
43. Variable expressivity in Patau syndrome is not all related to trisomy 13 mosaicism
Hui Fang Hsu
Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
Am J Med Genet A 143:1739-48
..Less associated anomalies such as polyhydramnios, oligohydramnios, intrauterine growth retardation, single umbilical artery, eye defects, holoprosencephaly, omphalocele, and polycystic kidney may contribute to their clinical courses...
44. Late childbearing and its impact on adverse pregnancy outcome: stillbirth, preterm delivery and low birth weight
P Astolfi
Department of Genetics and Microbiology A Buzzati Traverso, University of Pavia, Italy
Rev Epidemiol Sante Publique 53:2S97-105
..40 [1.33-1.47] in the least favourable conditions, and OR = 1.14 [1.08-1.21] in the most favourable conditions. This last, baseline risk might be indicative of a paternal genetic component associated with childbearing in advanced age...
45. Paternal age and spontaneous abortion
K Kleinhaus
Epidemiology Department, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Obstet Gynecol 108:369-77
OBJECTIVE: To evaluate the influence of paternal age upon spontaneous abortion...
46. Paternal age and schizophrenia: a population based cohort study
Attila Sipos
Academic Unit of Psychiatry, Cotham House, University of Bristol BS6 6JL
BMJ 329:1070
OBJECTIVE: To investigate the association of paternal age at conception with the risk of offspring developing schizophrenia. DESIGN: A population based cohort study. SETTING: Sweden...
47. Birth order, sibship size, and risk for germ-cell testicular cancer
Lorenzo Richiardi
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Epidemiology 15:323-9
..CONCLUSIONS: Sibship size, and not only birth order, is associated with testicular cancer risk. This suggests a higher prevalence of parental subfertility among patients with testicular cancer...
48. Obstetrical complications in people at risk for developing schizophrenia
Jacob S Ballon
Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, United States
Schizophr Res 98:307-11
..Obstetrical complications may be an important risk factor in identifying vulnerable subjects and ultimately may, along with other risk factors, be part of an algorithm for determining likelihood of developing schizophrenia...
49. Paternal age and maternal age are risk factors for miscarriage; results of a multicentre European study
Elise de La Rochebrochard
INED (National Demographic Studies Institute, 75020 Paris, France
Hum Reprod 17:1649-56
..However, studies usually investigate only maternal age effects. We investigated both maternal age and paternal age effects on miscarriage risk to provide insight into this frequent reproductive failure...
50. Delayed parenthood and the risk of cesarean delivery--is paternal age an independent risk factor?
Chao-Hsiun Tang
Associate Professor at the School of Health Care Administration, Taipei Medical University, Taiwan
Birth 33:18-26
..34 percent. This study set out to determine the independent effects of paternal age on the likelihood of cesarean delivery among a sample of Taiwanese women...
51. Late paternity and stillbirth risk
P Astolfi
Department of Genetics and Microbiology A Buzzati Traverso, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy
Hum Reprod 19:2497-501
..We examined the effect of paternal age on the complex multifactorial character, stillbirth...
52. What factors affect intracytoplasmic sperm injection outcomes?
Sacha Lewis
Department of Obstetrics and Gynecology, Kaiser Permanente of Southern California, Los Angeles, California, USA
Obstet Gynecol Surv 60:111-23
....
53. Paternal age and preterm birth
Helen Dolk
Epidemiology 17:593; author reply 593-4
54. [Parental age and genetic risks for the offspring]
M Vekemans
Département de Génétique et INSERM U393, Hôpital Necker Enfants Malades, 149 161, rue de Sèvres, 75743 Paris, France
Gynecol Obstet Fertil 30:831-3
..It is clear that the frequency at birth of some mendelian disorders is related to advanced paternal age, but this relationship is heterogeneous and varies from one disorder to another...
55. Cumulative incidence of type 1 diabetes in 10,168 siblings of Finnish young-onset type 1 diabetic patients
Valma Harjutsalo
Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
Diabetes 54:563-9
..This large prospective family study of type 1 diabetes in siblings of childhood-onset diabetic patients provides reliable empirical estimates for the sibling recurrence risk...
56. Advancing paternal age and autism
Abraham Reichenberg
Department of Psychiatry and Seaver Center for Autism Research, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Arch Gen Psychiatry 63:1026-32
..OBJECTIVE: To examine the relationship between advancing paternal age at birth of offspring and their risk of autism spectrum disorder (ASD)...
57. Parental age and risk of schizophrenia: a case-control study
Majella Byrne
National Centre for Register Based Research, Aarhus University, Aarhus, Denmark
Arch Gen Psychiatry 60:673-8
BACKGROUND: Advanced paternal age has been suggested as a possible risk factor for schizophrenia...
58. Risk factors of infant and child mortality in rural Burkina Faso
Heiko Becher
University of Heidelberg, Department of Tropical Hygiene and Public Health, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
Bull World Health Organ 82:265-73
..These findings illustrate the need for more comprehensive improvement of prenatal and postnatal care in rural sub-Saharan Africa...
59. Decreased sex ratio following maternal exposure to polychlorinated biphenyls from contaminated Great Lakes sport-caught fish: a retrospective cohort study
Marc G Weisskopf
Bureau of Environmental Health, Wisconsin Department of Health and Family Services, Madison, WI, USA
Environ Health 2:2
..and generalized estimating equations with adjustment for the year of birth of the child, maternal and paternal age, the mother's parity at the child's birth, and whether the child had an older brother...
60. Ionizing radiation and genetic risks. XI. The doubling dose estimates from the mid-1950s to the present and the conceptual change to the use of human data on spontaneous mutation rates and mouse data on induced mutation rates for doubling dose calculation
K Sankaranarayanan
Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Centre, Sylvius Laboratories, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
Mutat Res 453:107-27
..rate in humans differs between the two sexes (being higher in males than in females) and increases with paternal age. Further, an additional source of uncertainty in spontaneous mutation rate estimates in mice has been uncovered...
61. Birthweight, parental age, birth order and breast cancer risk in African-American and white women: a population-based case-control study
M Elizabeth Hodgson
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Breast Cancer Res 6:R656-67
..We also examined paternal age. Birthweight analyses were conducted for white and African-American women born in North Carolina on or after ..
62. The secular trends in male:female ratio at birth in postwar industrialized countries
P H Jongbloet
Department of Epidemiology and Biostatistics, University Medical Centre St Radboud, 6500 HB Nijmegen, The Netherlands
Environ Health Perspect 109:749-52
..In addition, none of the various family parameters (e.g., paternal age, maternal age, age difference in parents, birth order) could explain the historical time trends...
63. Testicular cancer risk and maternal parity: a population-based cohort study
T Westergaard
Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen
Br J Cancer 77:1180-5
..There was no association between testicular cancer risk and overall parity of the mother, maternal or paternal age at the birth of the son, or maternal age at first birth...
64. Ionizing radiation and genetic risks IX. Estimates of the frequencies of mendelian diseases and spontaneous mutation rates in human populations: a 1998 perspective
K Sankaranarayanan
MGC, Department of Radiation Genetics and Chemical Mutagenesis Sylvius Laboratories, Leiden University Medical Centre, Netherlands
Mutat Res 411:129-78
..several well-studied mendelian diseases, the mutation rate differs between the two sexes and it increases with paternal age. In estimates of spontaneous mutation rates in humans (which represent averages over both sexes), however, ..
65. Descriptive epidemiology of Cornelia de Lange syndrome in Europe
Ingeborg Barisic
Children s University Hospital Zagreb, Zagreb, Croatia
Am J Med Genet A 146:51-9
..Live born infants with CdLS have a high first week survival (91.4%). All patients were sporadic. Maternal and paternal age did not seem to be risk factors for CdLS...
66. Limb malformations with associated congenital constriction rings in two unrelated Egyptian males, one with a disorganization-like spectrum and the other with a probable distinct type of septo-optic dysplasia
Samia A Temtamy
Department of Clinical Genetics, Division of Human Genetics and Genome Research, National Research Centre, Cairo, Egypt
Clin Dysmorphol 19:14-22
..Both cases were sporadic and could be caused by a new dominant mutation because of the high paternal age of case 1 and the history of paternal occupational exposure to heat for both fathers...
67. [Chromosome aberrations in malformed newborns]
F Centeno Malfaz
Servicio de Pediatría Hospital Universitario del Río Hortega Valladolid
An Esp Pediatr 54:582-7
..17%. The mean age of mothers with Down's syndrome infants was 34.2 years and paternal age was 36 years, and a non-statistically significant diminishing trend in mean maternal age was observed during ..
68. [Epidemiological study on reduced folate carrier gene(RFC1 A80G) polymorphism and other risk factors of neural tube defects]
Li Jun Pei
Institute of Reproductive and Child Health, National Reference Laboratory on Reproductive Health Research, Ministry of Health, Peking University, Beijing 100083, China
Beijing Da Xue Xue Bao 37:341-5
..86-21.75). There were significant differences between cases and controls in the other risk factors, such as paternal age (> or =30), maternal fever during the early pregnancy, the history of maternal spontaneous abortion...
69. Maternal HIV status and pregnancy outcomes in northeastern Tanzania: a registry-based study
N A Habib
Department of Epidemiology and Biostatistics, Muhimbili University for Health and Allied Sciences, Dar es Salaam, Tanzania
BJOG 115:616-24
..Single motherhood, rural residence, low maternal education, maternal and paternal farming and higher paternal age were associated with unknown HIV status. About 7.4% (95% CI 6.7-8...
70. Suspected child abuse among victims of home accidents being admitted to the emergency department: a prospective survey from Turkey
Ozlem Gencer
Dokuz Eylul University School of Medicine, Department of Child and Adolescent Mental Health, Izmir, Turkey
Pediatr Emerg Care 22:794-803
..child's age younger than 12 months, having developmental delays in the social and self-care domains, younger paternal age, paternal alcohol abuse, marital discordancy, repeated history of home injuries, and requirement for ..
71. Sex ratio and associated risk factors for 50 congenital anomaly types: clues for causal heterogeneity
Monica Rittler
Latin American Collaborative Study of Congenital Malformations, WHO Collaborating Centre for the Prevention of Birth Defects ECLAMC at Hospital Materno Infantil Ramón Sardá, Buenos Aires, Argentina
Birth Defects Res A Clin Mol Teratol 70:13-9
..Multigravidity lowered the SR of SB(sHy) and HPP (HPP) cases. Increased paternal age inverted the SR of cleft lip (CL) with or without cleft palate (CL[P]) cases from male to female...
72. Cognitive development at age 8 years in very low birth weight children in Taiwan
Shu Chi Mu
Department of Pediatrics, Shin Kong Wu Ho Su Memorial Hospital, Institute of Clinical Medicine, National Yang Ming University, and College of Medicine, Fu Jen Catholic University, Taipei, Taiwan
J Formos Med Assoc 107:915-20
..Demographic data were recorded including maternal and paternal age, education, birth weight, gestational age, and gender...
73. A well-documented trisomy 13 case presenting with a number of common and uncommon features of the syndrome
Sevim Balci
Unit of Clinical Genetics, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
Turk J Pediatr 50:595-9
..This patient was the first child of unrelated parents with advanced maternal and paternal age, at 36 and 38 years, respectively. Unfortunately, the parents did not accept the prenatal diagnosis...
74. Predictors of infant mortality among college-educated black and white women, Davidson County, Tennessee, 1990-1994
A O Scott Wright
Department of Family and Preventive Medicine, Meharry Medical College, Nashville, Tennessee, USA
J Natl Med Assoc 90:477-83
..The following variables entered the logistic model process: maternal and paternal age; race and education; nativity status; maternal risk factors; interpregnancy interval; parity; infant gender; ..
75. Agenesis of the corpus callosum in California 1983-2003: a population-based study
Hannah C Glass
Department of Neurology, University of California, San Francisco, California 94143 0137, USA
Am J Med Genet A 146:2495-500
..7, 95% CI 2.5-5.3). After adjusting for paternal age, advanced maternal age >/=40 years was associated with ACC in infants with a chromosomal disorder (ACC RR 5...
76. Parental age at delivery, birth order, birth weight and gestational age are associated with the risk of childhood Type 1 diabetes: a UK regional retrospective cohort study
C R Cardwell
Department of Epidemiology and Public Health, The Queen s University of Belfast, Belfast, UK
Diabet Med 22:200-6
..RESULTS: Increased Type 1 diabetes risk was associated with higher maternal age, paternal age, birth weight and birth weight for gestational and lower gestational age...
77. Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia
F Rousseau
Service de Génétique, INSERM U 393, CNRS ER 88, Institut Necker, Hôpital des Enfants Malades, Paris, France
Nature 371:252-4
..More than 90% of cases are sporadic and there is an increased paternal age at the time of conception of affected individuals, suggesting that de novo mutations are of paternal origin...
78. Genetic factors in athetoid cerebral palsy
D J Amor
Genetic Health Services Victoria, Royal Children s Hospital, Parkville, Australia
J Child Neurol 16:793-7
..Factors suggesting a genetic cause were specifically sought, such as advanced paternal age, progression of symptoms, and associated congenital abnormalities...
79. Prevalence of congenital heart defects in patients with Down syndrome in the municipality of Pelotas, Brazil
Luciana T Vilas Boas
Universidade Católica de Pelotas UCPEL, Pelotas, RS, Brazil
J Pediatr (Rio J) 85:403-7
..Bivariate analysis between the outcome congenital heart defect and the predicting factors maternal age, paternal age, parents' and child's skin color, presence of other malformations and child's sex showed that the associations ..
80. Socio-economic determinants, maternal smoking and coffee consumption, and exclusive breastfeeding in 10205 children
Jonas F Ludvigsson
Department of Paediatrics, Orebro University Hospital, Sweden
Acta Paediatr 94:1310-9
..45-2.19), maternal employment less than 3 mo during pregnancy (95% CI AOR 1.17-1.54), paternal age81. The effect of birth order and parental age on the risk of type 1 and 2 diabetes among young adults
N Lammi
Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
Diabetologia 50:2433-8
..66, 95% CI 0.47-0.94) had a lower risk of type 2 diabetes than the first-born children. Maternal age, paternal age, and birth order did not have an effect on the risk of type 1 diabetes in the individuals aged 15-39 years at ..
82. Birth defects in uncles and aunts from Irish families with neural tube defects
Julianne Byrne
Boyne Research Institute, Duke House, Duke Street, Drogheda, Ireland
Birth Defects Res A Clin Mol Teratol 82:8-15
..4 vs. 4.0%, p = 0.01). The excess persisted after controlling with logistic regression models for maternal and paternal age, gender of uncle/aunt, proband's NTD diagnosis, and year of birth (OR 2.52; 95% CI: 1.29, 4.91; p = 0.007)...
83. Sex ratio in the offspring of parents with chronic radiation exposure from nuclear testing in Kazakhstan
Nadejda Y Mudie
Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
Radiat Res 168:600-7
..Sex ratio was significantly associated with maternal age, birth order and possibly ethnicity but not with paternal age, parental educational level or season...
84. Monozygotic twinning following assisted conception: an analysis of 81 consecutive cases
Mina Alikani
The Institute for Reproductive Medicine, 101 Old Short Hills Road, Suit 501, West Orange, NJ 07052, USA
Hum Reprod 18:1937-43
..MZ twinning was unrelated to maternal age, paternal age, gonadotrophin dosage, peak estradiol and progesterone levels, number of oocytes collected, and number of ..
85. Paternal origin of FGFR2 mutations in sporadic cases of Crouzon syndrome and Pfeiffer syndrome
R L Glaser
Department of Pediatrics, Center for Craniofacial Development and Disorders, McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Hum Genet 66:768-77
..4x10-7; 95% confidence limits 87%-100%). Advanced paternal age was noted for the fathers of patients with Crouzon syndrome or Pfeiffer syndrome, compared with the fathers of ..
86. Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best?
Matthew C Keller
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219
Behav Brain Sci 29:385-404; discussion 405-52
..of susceptibility alleles, and the increased risks of mental disorders with brain trauma, inbreeding, and paternal age. This evolutionary genetic framework for mental disorders has wide-ranging implications for psychology, ..
87. [Femur-fibula-ulna (FFU) complex in the 33rd week of gestation: ultrasonography, radiology, pathology and differential diagnosis. Case report]
M Guschmann
Abteilung für Paidopathologie und Plazentologie, Universitätsklinikum Charité, Virchow Klinikum, Medizinische Fakultät der Humboldt Universität zu Berlin, Germany
Klin Padiatr 213:301-5
..There are never found genetic abnormalities. Familial recurrence is not described. There is no maternal or paternal age effect on FFU-complex...
88. Factors affecting the incident juvenile bone tumors in an Austrian case-control study
Rainer Frentzel Beyme
Bremen Institute for Prevention Research, Social Medicine and Epidemiology, University of Bremen, Linzer Strasse 8, D 28359 Bremen, Germany
Cancer Detect Prev 28:159-69
..feeding for longer than 2 months was associated with low risk for bone tumors for boys, whereas for girls, paternal age was a risk factor; remaining stable in a multivariate model (RR = 2.36, 95% CI = 0.90-6.21)...
89. Can prematurity risk in twin pregnancies after in vitro fertilization be predicted? A retrospective study
Andrea Weghofer
Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria
Reprod Biol Endocrinol 7:136
..8%. Though maternal age significantly influenced prematurity risk (p < 0.05), paternal age, maternal body mass index, indications for fertility treatment, number of previous ART attempts, oocytes ..
90. CHARGE syndrome: report of 47 cases and review
A L Tellier
Département de Génétique et Unité de Recherches sur les Handicaps Génétiques de l Enfant, INSERM U 393, Hôpital Necker Enfants Malades, Paris, France
Am J Med Genet 76:402-9
..A significantly higher mean paternal age at conception together with concordance in monozygotic twins and the existence of rare familial cases support ..
91. Polyalanine expansion of PHOX2B in congenital central hypoventilation syndrome: rs17884724:A>C is associated with 7-alanine expansion
Hiroko Arai
Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan
J Hum Genet 55:4-7
..In spite of paternal bias, the paternal age effect on CCHS incidence was not observed...
92. Associations of pacifier use, digit sucking, and child care attendance with cessation of breastfeeding
Steven M Levy
Universit of Iowa, Iowa City 52242, USA
J Fam Pract 51:465
..variables (not planning to breastfeed, maternal smoking, infants' sex and antibiotic use, maternal and paternal age and education, and income group)...
93. Genotype and phenotype in patients with Prader-Willi syndrome in Taiwan
Hsiang Yu Lin
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
Acta Paediatr 96:902-5
..001), small hands and feet (p < 0.001), and hypopigmentation (p < 0.002). Both maternal (p = 0.015) and paternal age (p = 0.021) were higher in the UPD group...
94. Advanced parental age and the risk of autism spectrum disorder
Maureen S Durkin
Waisman Center, University of Wisconsin School of Medicine and Public Health, 789 WARF, 610 Walnut Street, Madison, WI 53726, USA
Am J Epidemiol 168:1268-76
This study evaluated independent effects of maternal and paternal age on risk of autism spectrum disorder...
95. Paternal and maternal ages at conception and risk of bipolar affective disorder in their offspring
P R Menezes
Department of Preventive Medicine, University of Sao Paulo, Brazil
Psychol Med 40:477-85
BACKGROUND: A consistent association between paternal age and their offspring's risk of schizophrenia has been observed, with no independent association with maternal age...
96. Parental age and risk of childhood cancer: a pooled analysis
Kimberly J Johnson
Division of Epidemiology Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
Epidemiology 20:475-83
..10 [1.04-1.17]). No maternal age effect was noted for retinoblastoma, germ cell tumors, or hepatoblastoma. Paternal age was not independently associated with most childhood cancers after adjustment for maternal age...