J Assist Reprod Genet. 2013 Jun 1. [Epub ahead of print]
High prevalence of isolated sperm DNA damage in infertile men with advanced paternal age.
Source
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Abstract
BACKGROUND:
Sperm DNA damage is associated with male infertility, lower pregnancy rates and pregnancy loss.
OBJECTIVE:
The primary aim of our study was to evaluate the prevalence of sperm DNA damage in younger and older men with normozoospermia.
DESIGN, SETTING AND PARTICIPANTS:
We obtained semen from 277 consecutive non-azoospermic men presenting for sperm DNA testing.
OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS:
The main outcome measures included sperm % DNA fragmentation index (%DFI, using sperm chromatin structure assay), sperm concentration, motility and morphology, and, paternal age.
RESULTS AND LIMITATIONS:
Sperm % DFI was positively correlated with paternal age (r = 0.20, P < 0.001) and inversely correlated % progressive motility (r = -0.16, P = 0.01). Sperm %DFI was significantly higher in older (≥40 years) compared to younger (<40 12="" 13="" 8="" and="" concentration="" damage="" different="" dna="" groups.="" high="" in="" levels="" men="" moreover="" morphology="" motility="" nbsp="" normozoospermic="" not="" of="" p="0.008)," prevalence="" progressive="" respectively="" significantly="" sperm="" the="" these="" two="" vs.="" were="" whereas="" years="">30 % DFI) was significantly higher in older compared to younger normozoospermic men (17 % vs. 3 %, respectively, P < 0.001).
CONCLUSION:
The data indicate that a conventional semen analysis can often fail to detect a defect in spermatogenesis (high %DFI) in older men and suggest that infertile couples with advanced paternal age, including those with normal semen parameters, should consider sperm DNA testing as part of the couple evaluation.
PMID: 23722935 [PubMed - as supplied by publisher]
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