Thursday, January 12, 2017

Jack Kruse Skin and eye

Skin and the RPE of the eye plays a role as biological active barrier to the external environment including sun exposure and the presence of cutaneous hyptothalamic-pituitary-adrenal axis (HPA) makes it an important peripheral neuroendocrine organ. The skin acts not only as a target for neuroendocrine signals but also a source of hormones and neurotransmitters, particularly the epidermis. As a result biological responses for pigmentation formation do not necessarily share the same mechanism of action to environmental insults including different wavelengths of sun exposure. A single exposure of UVB can induce delayed pigment formation preceded by an erythema response. UVA (320–400 nm) can induce IPD (immediate pigment darkening) during the first minutes of exposure, which is transient form of pigmentation and fades away within few hours, or PPD (persistent pigment darkening) that appears within hours of higher doses of UVA exposure and persist up to several days or weeks. Both IPD and PPD as well as erythema has been shown to be induced in skin phototypes I and II by single UVA exposure and some studies in fair skinned persons have also investigated the increase in pigmentation after multiple exposures of UVA. Traditionally skin pigmentation is believed as the most important photoprotective factor, since melanin, besides functioning as a broadband UV absorbent, has antioxidant and radical scavenging properties. However UVB induced melanin provides coverage against subsequent UV damage via increased melanin production supplemented by the redistribution of melanin towards the upper layers of the skin, whereas UVA induced tanning which is as result of photooxidation of existing melanin substrate provides very little coverage in the way of photoprotection. Neuropsin is the UVA skin/cornea photoillumination receptor. Although UVB and UVA portions of solar spectra are very well studied, but there is a lack of published studies on the effect of visible light of pigment induction in skin. Considering today's blue lit world this is something of a black hole in the literature and is the focus of this post. RF light is contained in most communication devices that humans use and both RF and blue light in man made lights have massive linked to Uveal melanoma in the eye. Red light has been shown to lower the risk of melanogenesis of the RPE of the retina but this color light has also been subtracted from modern man made lighting and communication devices while adding in massive amounts of blue light and RF radiation to the antenna sets. Both of these factors increase the blue light hazard for RPE and skin pigmentation where melanon is located in humans. Even light-emitting diodes at 830 and 850 nm (red light) have been shown to inhibit melanin synthesis and melanogenesis in vitro. You'd think the eye/skin doctors would get this information to people with uveal melanoma or skin cancer but it does not seem to making it to the public. People are completely unaware of how these light radiations can lead to cancers of the skin or the eye.

Although photobiologic studies of sunlight date back to Sir Isaac Newton in 1671, most available studies focus on the UV radiation part of the spectrum from artificial sources to make the link to cancers. The sun never emits UV light in isolation but the modern belief is that UV light from the continous solar spectrum must be pathologic. This idea is badly flawed. The effects of RF, visible light and infrared radiation have not been, until recently, clearly elucidated. You need to be aware of this "hole" in the literature. The paper below shows you just how deadly RF radiation and eye melanoma really is. Think about that everytime you use a cell phone close to thr side of your head where your eye is close. Or everytime you use a PEMF device on your head for sleep like the Oura ring. You might want to rethink those things. http://mobile.journals.lww.com/…/oaks.j…/articleviewer.aspx…

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